Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Diagnostic value of sheath-guided frozen biopsy technique for drug-induced interstitial lung disease

Chaoran Li, Xueâ€™e Wang, Sha Lu, Lei Yan, Yunkui Zhu

Department of Respiratory and Critical Care Medicine, Xiâ€™an International Medical Center Hospital, No. 777 Xitai Road, Xiâ€™an City, Shaanxi Province, China;

For correspondence:-

Accepted: 4 May 2023 Published: 30 May 2023

Citation: Li C, Wang X, Lu S, Yan L, Zhu Y. Diagnostic value of sheath-guided frozen biopsy technique for drug-induced interstitial lung disease. Trop J Pharm Res 2023; 22(5):1057-1064 doi: 10.4314/tjpr.v22i5.18

© 2023 The authors.
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Abstract

Purpose: To investigate the diagnostic value of sheath-guided frozen biopsy technique for interstitial lung disease (ILD).

Methods: In this retrospective study, 48 ILD patients of exclusive etiology admitted to Xi’an International Medical Center Hospital between October 1, 2021, and May 31, 2022, were randomly assigned to receive either endobronchial ultrasound with a guide sheath combined with transbronchial cryobiopsy TBCB (TBCB group), or endobronchial ultrasound with a guide sheath combined with transbronchial lung biopsy TBLB (TBLB group).

Results: The two groups were well-balanced in terms of baseline profiles (p = 0.94). The mean size of tissue blocks was 24.45 ± 2.83 mm² in TBCB group and 3.58 ± 0.89 mm² in TBLB group. TBCB and TBLB groups presented with a diagnostic accuracy of 64.00 % (16/25) and 69.57 % (16/23), respectively, while chi-square test demonstrated no significant difference between the two groups (p = 0.683). Chi-square test showed that there was significant difference in the incidence of complications (p = 0.036) as well as the incidence of bleeding (p = 0 .045), but no significant difference in the incidence of pneumothorax between the two groups (p = 0.605).

Conclusion: There are no significant differences in diagnostic sensitivity, specificity, and accuracy between endobronchial ultrasound sheath-guided frozen lung tissue biopsy and conventional clamped lung tissue biopsy for ILD, but the former has a lower incidence of complication than the latter. It is necessary to conduct a larger clinical study to further validate these findings

Keywords: Sheath-guided, Frozen biopsy of lungs, Interstitial lung disease, Diagnostic value